Program

June 15, 2012

13.00 – 14.30	Registration and Accommodation in Smolenice Castle
14.30 – 16.00	Light refreshment and coffee
16.00 – 16.20	Opening Address Chair: Krizanova O
16.20 – 17.05	WELCOME HONORARY LECTURE Wang R: Where, how, and what – H2S production and function
18.00	Welcome dinner

June 16, 2012

7.00 – 8.30	Breakfast
SESSION 1	HYDROGEN SULFIDE, HEART AND VASCULAR PHYSIOLOGY Chairs: Zhu YZ and Cirino G
8.15 – 8.45	A role for cystathionine γ-lyase/hydrogen sulfide in cardiovascular disease: Friend or foe? Pan L. L., Zhu Y. Z.
8.45 – 9.15	Role of cystathionine gamma lyase (CSE)-derived hydrogen sulfide in the pathogenesis of heart failure Lefer D. J.
9.15 – 9.30	H2S preconditioning of therapeutically used stem cells increases their survival and efficacy in an in vitro model of cell-based therapy in myocardial infarct Benko Z., Dongo E., Csizmazia A., Szepes M., Janicsek Z., Kiss L.
9:30 – 10.00	cGMP-dependent protein kinase contributes to hydrogen sulfide-induced vasorelaxation Cirino G,  Ianaro A,  Cantalupo A,  Feil R,  Papapetropoulos A,  Bucci M
10.00 – 10.15	Specific gender-related difference in biosynthesis and release of H2S in isolated rat aorta Ianaro A,  Bucci M,  Vellecco V,  Panza E,  Roviezzo F,  Brancaleone V,  Cirino G
10.15 – 10.30	InvolvementInvolvement of L-cysteine/H2S pathway in human bladder homeostasis d'Emmanuele di Villa Bianca R., Mitidieri E., Fusco F., Mirone V., Sorrentino R., Cirino G.
10.30 – 11.00	COFFEE BREAK
SESSION 2	H2S AND NO CROSS-TALK Chairs: Hart JL, Winyard PG
11.00 – 11.30	Hydrogen sulfide mediates the conversion of nitrite and S-nitrosothiols to nitric oxide: a potential mechanism to explain the physiological effects of nitrate ingestion in humans Winyard PG,  Lo Faro ML,  Whatmore J,  Whiteman M
11.30 – 11.45	Hydrogen sulfide treatment reduces vascular oxidative stress in angiotensin II-induced hypertension in mice Al-Magableh MR,  Kemp-Harper BK,  Hart JL
11.45 – 12.00	Interdependence of NO and H2S for angiogenesis and vasorelaxation Coletta C,  Papapetropoulos A,  Erdelyi K,  Olah G,  Modis K,  Panopoulos P,  Gero D,  Szabo C
12.00 – 12.30	H2S signaling and functions in endothelial cells Papapetropoulos A.
12.30 – 14.00	LUNCH
SESSION 3	HYDROGEN SULFIDE, REGULATION OF RESPIRATORY AND GASTROINTESTINAL FUNCTION Chairs: Zheng Y, Wallace JL
14.00 – 14.30	Hydrogen sulfide is a pro-resolution mediator in the digestive tract Wallace JL
14.30 – 14.45	Hydrogen sulfide as a modulator of gastrointestinal motility Jimenez M
14.45 – 15.00	Protective effects of hydrogen sulfide on medullary respiratory centers against injury induced by acute hypoxia in adult rats Li Hui,  Chen Li,  Hou Xuefei,  Ding Yan,  Nie Zheng,  Tang Yuhong,  Zhou Hua,  Zheng Yu
15.00 – 15.30	H2S levels in chronic airways disease and its impact on airway smooth muscle cell function Kirkham P,  Adcock I,  Perry M,  Chung KF
15.30 – 15.45	The brain and hypertension, is hydrogen sulfide involved? Ufnal M
15.45 – 16.00	The role of hydrogen sulfide in the neurogenic regulation of the circulatory system Sikora M,  Ufnal M
16.00 – 16.30	COFFEE BREAK
SESSION 4	HYDROGEN SULFIDE DONORS Chairs: Lefer D. J., Whiteman M
16.30 – 17.00	Hydrogen sulfide and arthritis – a novel therapeutic opportunity? Whiteman M
17.00 – 17.15	Slow release H2S donors protect human microvascular endothelial cells from oxidative stress and staurosporine induced cell death: novel role of mitochondria-targeted H2S donors Bełtowski J,  Guranowski A
17.15 – 17.30	Slow release H2S donors protect human microvascular endothelial cells from oxidative stress and staurosporine induced cell death: novel role of mitochondria-targeted H2S donors Le Trionnaire S., Whatmore J. L., Perry A., Wood M. E., Whiteman M.
17.00 – 17.15	Protective effects of exogenous hydrogen sulfide and cystathionine-γ-lyase (CSE)-derived H2S in the carrageenan (CGN)-induced rat knee joint synovitis Ekundi-Valentim E,  Rodrigues L,  Santos KT,  Moreira D,  Teixeira SA,  Belizario JE,  Munhoz CD,  Wallace JL,  Muscara MN,  Costa SKP
17.30 – 17.45	Characterising the effect of novel slow-release H2S donors on pro-inflammatory enzyme activity Fox B,  Holland T,  Perry A,  Winyard PG,  Wood ME, Whiteman M
18.00 – 19.25	Poster presentations and discussion
19.30	Barbecue and folk music

June 17, 2012

7.00 – 8.30	Breakfast
SESSION 5	HYDROGEN SULFIDE AND DIABETES – THERAPEUTIC OPPORTUNITIES? Chairs: Costa SK, Szabo C
8.30 – 9.00	Role H2S deficiency in the pathogenesis of diabetic vascular complications Szabo C
9.00 – 9.15	Hydrogen sulfide therapy preconditions the db/db diabetic mouse heart against ischemic injury by overcoming an impairment in NRF2 signaling Moody BF,  Nicholson CK,  Calvert JW
9.15 – 9.30	H2S – a novel guardian of the endothelial glycocalyx? Wolanska KI,  Perry A,  Wood ME,  Chibbe R,  Whatmore JL,  Whiteman M
9:30 – 10.00	Inhibition of calcification and osteoblastic differentiation of vascular smooth muscle cells by hydrogen sulfide Zavaczki E,  Jeney V,  Agarwal A,  Zarjou A,  Oros M,  Katko M,  Varga ZS,  Balla GY, Balla J
10.00 – 10.15	H2S donors and their potential therapeutic application in pruritus Rodrigues L,  Ekundi-Valentim E,  Florenzano J,  Teixeira SA,  Muscara MN, Costa SK
10.15 – 10.30	The impact of hydrogen sulfide on neurotransmitter release from the cat carotid body Fitzgerald RS, Shirahata M, Kostuk E, Kiihl S
10.30 – 11.00	COFFEE BREAK
SESSION 6	HYDROGEN SULFIDE AND MITOCHONDRIA Chairs: Starikova EG, Papapetropoulos A
11.00 – 11.30	Mitochondrial oxidation of sulfide Bouillaud F,  Blachier F,  Mimoun S,  Andriamihaja M
11.30 – 11.45	Cooperative interactions of H2S and krebs cycle-derived electron donors in maintenance of mitochondrial electron transport and cellular bioenergetics Modis K,  Coletta C,  Papapetropoulos A,  Szabo C
11.45 – 12.00	Interactions of hydrogen sulfide with cytochrome c oxidase Marshall DC,  Nicholls P,  Wilson MT,  Cooper CE
12.00 – 12.15	p38 MAPK-dependent targets of hydrogen sulfide proapoptotic action in Jurkat cells Starikova EG,  Tashireva LA,  Novitsky VV,  Ryazantseva NV
12.15 – 12.30	Interactions of hydrogen sulfide with neutrophil-derived oxidants Nagy P.
12.30 – 14.00	LUNCH
SESSION 7	HYDROGEN SULFIDE SYNTHESIS - CBS, CSE AND 3-MST Chairs: Wróbel M, Kimura H
14.00 – 14.30	H2S production by 3MST and its physiological role in the retina Kimura H
14.30 – 14.45	Cystathionine beta-synthase deficiency in humans and hydrogen sulfide metabolism Kozich V,  Krijt J,  Hnizda A
14.45 – 15.00	Caenorhabditis elegans possesses four genes encoding cystathionine beta-synthase-related proteins with distinct role in H2S biology Krijt J,  Horvitz HR,  Kozich V
15.00 – 15.15	The enzymatic systems generating sulfane sulfur and sulfide Wrobel M., Bronowicka-Adamska P.
15.15 – 15.30	Redox signalling via the cellular thiolstat – A tale of sulfanes and sulfides Jacob C, Burkholz T, Schneider T, Czepukojc B, Khairan K
15.30 – 15.45	Modulation of H2S induced NO release from S-nitrosoglutathione by oxygen, pH and low molecular thiols Ondrias K., Grman M., Misak A., Tomaskova Z., Bertova A.
15.45 – 16.00	Product(s) of H2S - NO interaction and relaxation of aortic rings Cacanyiova S., Kristek F., Misak A., Ondrias K.
16.00 – 16.30	COFFEE BREAK
SESSION 8	HYDROGEN SULFIDE AND ION CHANNELS Chairs: Ondrias K, Kawabata A
16.30 – 17.00	Hydrogen sulfide and bladder pain Kawabata A,  Matsunami M,  Okawa Y
17.00 – 17.15	Hydrogen sulfide and calcium signaling in cardiomyoblasts and endothelial cell functional effects Avanzato D,  Pupo E,  Fiorio Pla A,  Mancardi D,  Munaron L
17.15 – 17.30	Slow release H2S donor GYY4137 causes translocation of IP3 receptors to nuclei Krizanova O., Ondrias K., Csaderova L., Wood M. E., Whiteman M., Lencesova L.
17.30 – 17.45	Hydrogen sulfide activates BK channels – role of phosphorylation Sitdikova GF,  Weiger TM,  Hermann A
18.00 – 18.45	Discussion – European H2S Conferences
19.00	Farewell dinner

June 18, 2012

7.00 – 8.30	Breakfast
SESSION 9	HYDROGEN SULFIDE, CELLULAR STRESS AND CELL PROLIFERATION Chairs: Pushchina EV, Ahmed A
8.30 – 9.00	Hydrogen sulfide protects dopaminergic neuron against degeneration by attenuation of endoplasmic reticulum stress Bian J.
9.00 – 9.30	The impact of dysregulation of the hydrogen sulfide producing enzyme cystathionine γ-lyase in preeclampsia Ahmed A.
9:30 – 09.45	The effects of novel slow releasing H2S donors on T-cell proliferation Holland T., Fox B., Perry A., Wood M. E., Whiteman M.
9:45 – 10.00	High concentrations of hydrogen sulfide elevate the expression of a series of pro-inflammatory genes in fibroblast-like synoviocytes derived from rheumatoid and osteoarthritis patients Kloesch B., Liszt M., Krehan D., Dietersdorfer E., Kiener H., Steiner G.
10.00 – 10.15	Hydrogen sulfide as regulator functional activity in teleost fishes brain Pushchina E. V., Obukhov D. K., Varaksin A. A.
10.15 – 10.30	Epigenetic Events Associated With Sulfur-Containing Natural Products Burkholz T, Schneider T, Czepukojc B, Jacob C
10.45 – 11.00	COFFEE BREAK
11.00 – 11.20	Young Investigator Awards for best presentations (PhD students and post-docs)
11.20 – 11.30	Concluding remarks
11.30 – 12.30	LUNCH
13.00	Bus departure to Bratislava

Posters

P1	Specificity of calcium signaling induced by hydrogen sulfide in different endothelial cell types Avanzato D., Mancardi D., Moccia F., Munaron L.
P2	Hydrogen sulfide, an efficient endogenous inhibitor of human myeloperoxidase Palinkas Z., Nagy A., Nagy P.
P3	Kinetics and Mechanism of the Reactions of Hydrogen Sulfide with Amino Acid Chloramines Vasas A., Fábián I., Nagy P.
P4	Inhibition of staurosporine-induced microvascular endothelial apoptosis by novel slow release hydrogen sulfide donors Le Trionnaire S.
P5	The H2S-donor sodium hydrogen sulphide and sulphur containing molecules such as dimethyl sulphoxide and dimethyl sulphone block LPS and IL-1β-induced IL-6 expression in human synovial fibroblasts Kloesch B., Dietersdorfer E., Liszt M., Steiner G.
P6	Hydrogen Sulphide and the Pathophysiology of Sensitized Airway Smooth Muscle Cheng Z. Q., Ji S., Stephens N. L., Fitzgerald R. S., Cenkowski S.
P7	Mechanisms of negative inotropic effect of hydrogen sulfide in frog myocardium Sitdikova G. F., Zefirov A. L.
P8	Comparative effects of naproxen (NAP) and ATB-346 - a hydrogen sulfide (H2S)-releasing NAP - on carrageenan (CGN)-induced synovitis in rats Ekundi-Valentim E., Rodrigues L., Santos K. T., Teixeira S. A., Wallace J. L., Costa S. K. P., Muscara M. N.
P9	Experimental outcomes of endogenous H2S in the rat acute pancreatitis evoked by secretory phospholipase A2 from Crotallus durissus terrificus (Cdt) venom Zanoni C. I., Rodrigues L., Camargo E., Ekundi-Valentim E., Teixeira S. A., Muscara M. N., Costa S. K. P.
P10	The uremic toxin cyanate abrogates the radical scavenging ability of hydrogen sulfide Laggner H., Praschberger M., Hermann M., Gmeiner B. M. K.
P11	Selectivity of commonly used pharmacological inhibitors for cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE) Asimakopoulou A., Panopoulos P., Chasapis C., Giannis A., Spyroulias G. A., Papapetropoulos A.
P12	Slow release H2S donor AP39 Malekova M., Perry M., Kristek F., Wood M. E., Cacanyiova S., Whiteman M., Ondrias K.
P13	A possible involvement of „sulfide signalling“ in the Na+/Ca2+ exchanger regulation can be through the β adrenergic receptors Markova J., Lencesova L., Whiteman M., Hudecova S., Ondrias K., Krizanova O., Wood M. E.
P14	Interaction of H2S with low molecular thiols and NO release from nitrosoglutathione Misak A., Grman M., Liptaj T., Pronayova N., Ondrias K.
P15	H2S - NO interaction in aqueous solution Grman M., Misak A., Ondrias K.